Can i clean my computer with a motorised duster?

If it's the one I'm thinking of, a bit like a feather duster that revolves, only with nylon strands instead of feathers, it looks very likely to cause static problems. Personally, I wouldn't use it. Myself, I use a paintbrush (reserved from new for that purpose only) with the nozzle of a vacuum cleaner held nearby if required. A can of compressed "air" is also useful.